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Researchers also assessed the overall nitrogen balance and proposed a hypothesis about nitrogen distribution across different organs

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4.3 Renal fibrosis and extracellular matrix remodeling Renal fibrosis is the common pathological endpoint of various chronic kidney diseases (CKD) and is characterized by fibroblast activation, epithelial-to-mesenchymal transition (EMT), and abnormal accumulation of the extracellular matrix (ECM), ultimately leading to nephron destruction and loss of function ( -SMA and collagen I, promoting interstitial remodeling

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